New approach to treating Alzheimer's disease receives major NIA backing
Given the enormous and growing impact of Alzheimer’s on patients and families, there is an urgent need to develop and rigorously evaluate a larger and more diversified portfolio of promising late clinical stage treatments
T3D Therapeutics, a clinical stage drug development company engaged in the development of T3D-959 (the “Company”), a new orally administered treatment for Alzheimer’s disease (AD), announced that it has received a grant expected to total $9 million dollars over four years from the National Institute on Aging (NIA), part of NIH, to help fund a Phase 2 clinical study of T3D-959, a novel, metabolic-focused AD drug treatment.
The Phase 2 PIONEER study (Prospective therapy to Inhibit and Overcome Alzheimer’s Disease Neurodegeneration via Brain EnErgetics and Metabolism Restoration) is expected to initiate patient dosing in early 2020. PIONEER is a double-blind, placebo-controlled, parallel-group Phase 2 safety and efficacy study expected to enroll up to 252 adults with mild-to-moderate Alzheimer’s disease (MMSE 16-26). PIONEER will enroll subjects who will receive one of three different doses of T3D-959 or a placebo for 24 weeks.
“We see this grant award as recognition that improving inherent metabolic defects in Alzheimer’s disease is a vital and largely unexplored therapeutic avenue in need of pursuit is a testament to the potential for T3D-959 to treat AD, a disease that we view as a chronic anorexia of the brain” said Chief Executive Officer John Didsbury, Ph.D. “We are truly honored by the support of the NIA and the confidence that our peers have shown in the science underpinning T3D-959.”
“Given the enormous and growing impact of Alzheimer’s on patients and families, there is an urgent need to develop and rigorously evaluate a larger and more diversified portfolio of promising late clinical stage treatments,” said George Vradenburg, Chairman and Co-Founder of UsAgainstAlzheimer’s. “NIA’s support of Phase 2 studies – including this study from T3D Therapeutics – is to be commended and scaled if we are going to achieve our national goal of effectively treating Alzheimer’s in the near future.”