HIPEC gaining ground in treating peritoneal cancer and other health conditions

Peritoneal cancers are increasing worldwide

Dr. Anil Kamath
Dr. Anil Kamath

Dr Anil Kamath, Senior Consultant and Surgical Oncologist at Apollo Hospital, disclosed that the number of patients diagnosed with peritoneal cancers is increasing.
“Previously, knowledge about peritoneal cancer was very limited but, through the years and thanks to advancements in the field of medicine, we have come to understand the disease better. Today globally more than half a million patients are affected by either primary or secondary peritoneal cancers,” Dr Kamath said.

With the surge in the number of cases, Dr Kamath said many specialists worldwide are now using the Hyperthermic Intraperitoneal Chemotherapy (HIPEC) method as part of the treatment process for patients diagnosed with the disease and other relevant health conditions.
HIPEC is an alternative method of administering chemotherapy to the patient. It is used when we need large dosage of medicine is needed to reach the peritoneum. HIPEC is often used in combination with intravenous chemotherapy.

HIPEC  is now a well-accepted treatment modality for pseudomyxoma peritonei, a type of cancer in which mucous producing cells deposit in the abdomen causing it to bloat with jelly like material. This condition usually develops because of tumors in the appendix.

HIPEC is also used in mesothelioma, a cancer that starts in the peritoneum related to asbestos exposure; ovarian cancer with peritoneal metastases and high risk of recurrence; recurrent ovarian cancer with limited peritoneal metastases; and stomach cancer with limited peritoneal and omental deposits.

“Few randomized trials have shown that the survival rate of patients with stage 3c ovarian cancer who were treated with surgery and HIPEC has improved by more than a year as compared to surgery alone. HIPEC offers hope of cure to certain patients with an otherwise incurable disease. This is especially true to individuals with pseudomyxoma who, apart from surgery and HIPEC, have hardly any option in terms of treatment. If the impact of the disease is still limited, then chances of cure are always high,” Dr Kamath said.

Across various Apollo Hospitals, almost 800 to 1,000 patients have undergone HIPEC procedure. The safety of the procedure has been positive, with less than 5 per cent post-operative mortality. The clinical outcomes, meantime, have been mixed depending on the condition for which it has been performed.